It is possible that there are many ‘causes’ of cognitive decline. Exercise is known to combat both frailty and cognitive decline.
Research carried in Plos Biology showed that age-related changes occur in the expression of genes relevant to the vascular system in the brain cotex – capiliaries and other blood-brain barrier maintenance factors were lost. Inflammation was another feature as was a loss in immune scavengers that keep the brain clear and ‘clean’.
The research team found that all these ‘declines’ were reduced in individuals who took regular exercise.
Interestingly, those subjects who were deficient in a gene called Apoe, a known risk factor for Alzheimer’s, did not benefit from exercise.