Berberine may have greater potential than temozolomide in brain cancer

Herb potentially treats brain cancer better than Temozolomide

Chinese Medical Scientists from Shandong Medical School have shown that the herb Berberine down-regulates brain cancer cells better than Temozolomide in controlled in vitro experiments.

Previous studies have shown that Berberine exerts its effects through apoptosis and glioblastoma cell death, however this study indicated a further action: The EGFR pathway was inhibited causing cell senescence and down-regulation.

Glioblastomas particularly use EGFR signaling; but so do many other cancers. With Berberine the RAF-MEK-ERK was 'remarkably inhibited'.

The scientists ended their report on the study by saying that this was a completely new route discovered for the anti-cancer benefits of Berberine, and they felt it should be seriously considered as a part of a package of treatments for brain cancer and Glioblastomas.

Ref: Mol Cancer Ther. 2015 Feb;14(2):355-63. doi: 10.1158/1535-7163.MCT-14-0634. Epub 2014 Dec 12.